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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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In conclusion, titanium dioxide is an essential ingredient in the production of high-quality paper products, helping to ensure that papers are not only visually appealing but also durable and long-lasting. Its versatility and effectiveness make it a popular choice for paper manufacturers looking to enhance the performance and aesthetics of their products. Whether used in coated papers, specialty papers, or archival papers, titanium dioxide continues to be a key component in the success of the paper industry.

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